Article
HPV DNA and p53 alterations in oropharyngeal carcinomas.
Virchows Archiv : an international journal of pathology - 1 Jan 1995
Barten M, Ostwald C, Milde-Langosch K, Müller P, Wukasch Y, Löning T
Abstract excerpt
We have examined a series of 37 oropharyngeal squamous cell carcinomas for the presence of HPV 6/11, 16, and 18 DNA by polymerase chain reaction (PCR)/Southern blotting and for p53 alterations by immunohistochemistry and mutation screening with temperature gradient gel electrophoresis (TGGE). HPV sequences were found in a total of 26 of 37 cancers (70.3%), most frequently HPV 16 (20/37) followed by HPV 18...
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