HPV DNA and p53 alterations in oropharyngeal carcinomas.

doi:10.1007/BF00196520

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Article

HPV DNA and p53 alterations in oropharyngeal carcinomas.

Virchows Archiv : an international journal of pathology - 1 Jan 1995

Barten M, Ostwald C, Milde-Langosch K, Müller P, Wukasch Y, Löning T

Abstract excerpt

We have examined a series of 37 oropharyngeal squamous cell carcinomas for the presence of HPV 6/11, 16, and 18 DNA by polymerase chain reaction (PCR)/Southern blotting and for p53 alterations by immunohistochemistry and mutation screening with temperature gradient gel electrophoresis (TGGE). HPV...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
DNA, Viral
Female
Genes, p53
Humans
Male
Middle Aged
Mutation
Oropharyngeal Neoplasms
Papillomaviridae
Tumor Suppressor Protein p53

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