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A DNA adenine methylase mutant of Shigella flexneri shows no significant attenuation of virulence.

Microbiology (Reading, England) - 1 Apr 2004

Honma Yasuko, Fernández Reinaldo E, Maurelli Anthony T

Abstract excerpt

Mutants of Salmonella defective in DNA adenine methylase (dam) have been reported to be attenuated for virulence and to provide protective immunity when used as vaccine strains. To determine whether these observations could be extended to Shigella, a dam mutant of Shigella flexneri 2a was characterized and examined for the role of dam in pathogenesis. The Shigella dam mutant showed some unique characteristics;...

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PMID: 15073316
DOI: 10.1099/mic.0.26781-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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