Mapping of the mutations present in the genome of the Rift Valley fever virus attenuated MP12 strain and their putative role in attenuation.

doi:10.1016/s0168-1702(97)00097-x

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Article

Mapping of the mutations present in the genome of the Rift Valley fever virus attenuated MP12 strain and their putative role in attenuation.

Virus research - 1 Nov 1997

Vialat P, Muller R, Vu T H, Prehaud C, Bouloy M

Abstract excerpt

The MP12 attenuated strain of Rift Valley fever virus was obtained by 12 serial passages of a virulent isolate ZH548 in the presence of 5-fluorouracil (Caplen et al., 1985. Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development. J. Gen. Virol., 66, 2271-2277)....

Topics

Animals
Chlorocebus aethiops
DNA Mutational Analysis
Genome, Viral
Mutation
Polymerase Chain Reaction
Rift Valley fever virus
Vero Cells
Viral Proteins
Virulence

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