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Article

Mechanisms of temperature sensitivity of attenuated Urabe mumps virus.

Virus research - 2 Jan 2017

Schinkel Stephanie C Burke, Rubin Steven, Wright Kathryn E

Abstract excerpt

Temperature sensitivity is a phenotype often associated with attenuation of viruses. Previously, we purified several mumps variants from an incompletely attenuated Urabe strain live attenuated vaccine. Here we characterize one isolate that is sensitive to growth at high temperature. This virus was attenuated in a small animal model of mumps virulence, and we identified unique coding substitutions in the...

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PMID: 27720824
DOI: 10.1016/j.virusres.2016.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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