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Article

Use of reassortant viruses to map attenuating and temperature-sensitive mutations of the Rift Valley fever virus MP-12 vaccine.

Vaccine - 1 Aug 1990

Saluzzo J F, Smith J F

Abstract excerpt

A live-attenuated vaccine for Rift Valley fever virus (RVFV), MP-12, has been developed recently by undirected, serial mutagenesis of a RVFV strain (ZH548) isolated during the 1977 epidemic in Egypt. In the present study, the mutations responsible for attenuation of this virus have been examined...

Topics

Animals
Antibodies, Monoclonal
Antigens, Viral
Bunyaviridae
Chromosome Mapping
Clone Cells
Humans
Mice
Mutation
Phenotype
Rift Valley fever virus
Temperature
Vaccines, Attenuated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2396475
DOI: 10.1016/0264-410x(90)90096-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2396475-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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