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Article

Genetic subpopulations of Rift Valley fever virus strains ZH548 and MP-12 and recombinant MP-12 strains.

Journal of virology - 1 Dec 2012

Lokugamage Nandadeva, Freiberg Alexander N, Morrill John C, Ikegami Tetsuro

Abstract excerpt

Rift Valley fever virus strain MP-12 was generated by serial plaque passages of parental strain ZH548 12 times in MRC-5 cells in the presence of a chemical mutagen, 5-fluorouracil. As a result, MP-12 encoded 4, 9, and 10 mutations in the S, M, and L segments, respectively. Among them, mutations in the M and L segments were responsible for attenuation, while the MP-12 S segment still encoded a virulent phenotype....

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Identifiers

PMID: 23035230
DOI: 10.1128/JVI.02081-12
PMCID: PMC3503115

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