Soluble ecto-domain mutant of thyrotropin (TSH) receptor incapable of binding TSH neutralizes the action of thyroid-stimulating antibodies from Graves' patients.

doi:10.1210/endo.139.2.5748

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Article

Soluble ecto-domain mutant of thyrotropin (TSH) receptor incapable of binding TSH neutralizes the action of thyroid-stimulating antibodies from Graves' patients.

Endocrinology - 1 Feb 1998

Osuga Y, Liang S G, Dallas J S, Wang C, Hsueh A J

Abstract excerpt

A soluble form of the amino-terminal extracellular (ecto-) domain of the human TSH receptor was generated. This protein was capable of binding TSH and autoimmune antibodies found in Graves' patients. A deletion mutant of the ectodomain lacking nine amino acids in the C-terminal region lost its ab...

Topics

Autoantibodies
Cell Line
Cyclic AMP
Graves Disease
Humans
Immunoglobulin G
Mutation
Peptide Fragments
Receptors, Thyrotropin
Solubility
Thyrotropin

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