Article
Use of thyrotropin receptor (TSHR) mutants to detect stimulating TSHR antibodies in hypothyroid patients with idiopathic myxedema, who have blocking TSHR antibodies.
The Journal of clinical endocrinology and metabolism - 1 Jul 1993
Kosugi S, Ban T, Akamizu T, Valente W, Kohn L D
Abstract excerpt
Deletions of residues 295-306, 299-301, and 387-395 of the TSH receptor, as well as point mutations of cysteine 301 or 390 to serine, and tyrosine 385 to phenylalanine or alanine, markedly diminish the ability of a transfected receptor to measure the activity of blocking TSH receptor autoantibodi...
Topics
- Animals
- Autoantibodies
- Autoimmune Diseases
- Cell Line
- Cyclic AMP
- Gene Deletion
- Graves Disease
- Humans
- Hypothyroidism
- Immunoglobulin G
- Immunoglobulins, Thyroid-Stimulating
- Mutation
- Myxedema
- Point Mutation
- Receptors, Thyrotropin
- Thyrotropin
- Transfection