Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains.

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Article

Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains.

The Journal of biological chemistry - 15 Oct 1991

Kosugi S, Ban T, Akamizu T, Kohn L D

Abstract excerpt

Residues 287 to 404 of the rat thyrotropin (TSH) receptor exhibit little homology to gonadotropin receptors. A large segment of this region, residues 303-382, has no determinants important for TSH to bind or elevate cAMP levels nor for the activity of thyroid-stimulating autoantibodies (TSAbs) from the sera of Graves' patients, i.e. deletions, substitutions, or mutations in this segment do not result in a loss of...

Topics

Amino Acid Sequence
Animals
Autoimmune Diseases
Cell Line
Cyclic AMP
DNA
Enzyme-Linked Immunosorbent Assay
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rats

Receptors, Gonadotropin

Receptors, Thyrotropin

Sequence Homology, Nucleic Acid

Swine

Thyroid Diseases

Transfection

Source

Open in PubMed

Identifiers

PMID: 1655787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1655787-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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