Article
Novel mutations in the estrogen receptor messenger RNA in human breast cancers.
The Journal of clinical endocrinology and metabolism - 1 Apr 1996
Murphy L C, Wang M, Coutt A, Dotzlaw H
Abstract excerpt
One mechanism that has been suggested to play a role in the progression of human breast cancer from hormone dependence to independence is the expression or altered expression of mutant and/or variant forms of estrogen receptor (ER). Two major types of variant ER messenger (m)RNA have been identified in human breast biopsy samples so far: truncated transcripts and exon deleted transcripts. In this study we provide...
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