Article
Characterization of estrogen receptor variant mRNAs from human breast cancers.
Molecular endocrinology (Baltimore, Md.) - 1 May 1992
Dotzlaw H, Alkhalaf M, Murphy L C
Abstract excerpt
The cDNAs for variant estrogen receptor (ER) mRNAs previously identified in human breast cancer biopsy samples have been cloned and characterized. Some of these cDNAs are unique to a tumor sample (e.g. clones 24 and 5), while others are present in multiple breast tumor samples (e.g. clone 4). The 5' ends of the variant cDNAs are essentially identical to sequences present in exons 1, 2, and 3 of the normal ER...
Topics
- Amino Acid Sequence
- Base Sequence
- Breast Neoplasms
- Cloning, Molecular
- Gene Library
- Genetic Variation
- Humans
- Molecular Sequence Data
- RNA, Messenger
- RNA, Neoplasm
- Receptors, Estrogen