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Article

Human rhinovirus capsid dynamics is controlled by canyon flexibility.

Virology - 15 Sept 2003

Reisdorph Nichole, Thomas John J, Katpally Umesh, Chase Elaine, Harris Ken, Siuzdak Gary, Smith Thomas J

Abstract excerpt

Quantitative enzyme accessibility experiments using nano liquid chromatography electrospray mass spectrometry combined with limited proteolysis and isotope-labeling was used to examine the dynamic nature of the human rhinovirus (HRV) capsid in the presence of three antiviral compounds, a neutralizing Fab, and drug binding cavity mutations. Using these methods, it was found that the antivirals WIN 52084 and...

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Identifiers

PMID: 14517058
DOI: 10.1016/s0042-6822(03)00452-5

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