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Article

Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity.

Molecular and cellular biology - 1 May 2003

Sierra Jose, Villagra Alejandro, Paredes Roberto, Cruzat Fernando, Gutierrez Soraya, Javed Amjad, Arriagada Gloria, Olate Juan, Imschenetzky Maria, Van Wijnen Andre J, Lian Jane B, Stein Gary S, Stein Janet L, Montecino Martin

Abstract excerpt

p300 is a multifunctional transcriptional coactivator that serves as an adapter for several transcription factors including nuclear steroid hormone receptors. p300 possesses an intrinsic histone acetyltransferase (HAT) activity that may be critical for promoting steroid-dependent transcriptional activation. In osteoblastic cells, transcription of the bone-specific osteocalcin (OC) gene is principally regulated by...

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Identifiers

PMID: 12697832
DOI: 10.1128/MCB.23.9.3339-3351.2003
PMCID: PMC153185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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