Article
Iodide suppression of major histocompatibility class I gene expression in thyroid cells involves enhancer A and the transcription factor NF-kappa B.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1998
Taniguchi S I, Shong M, Giuliani C, Napolitano G, Saji M, Montani V, Suzuki K, Singer D S, Kohn L D
Abstract excerpt
High concentrations of iodide can induce transient, clinical improvement in patients with autoimmune Graves' disease. Previous work has related this iodide action to the autoregulatory effect of iodide on the growth and function of the thyroid; more recently, we additionally related this to the ability of iodide to suppress major histocompatibility (MHC) class I RNA levels and antigen expression on thyrocytes. In...
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