Article
Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism.
The Journal of biological chemistry - 9 Sept 2011
Stefan Mihaela, Jacobson Eric M, Huber Amanda K, Greenberg David A, Li Cheuk Wun, Skrabanek Luce, Conception Erlinda, Fadlalla Mohammed, Ho Kenneth, Tomer Yaron
Abstract excerpt
Autoimmune thyroid diseases (AITD) arise from complex interactions between genetic, epigenetic, and environmental factors. Whole genome linkage scans and association studies have established thyroglobulin (TG) as a major AITD susceptibility gene. However, the causative TG variants and the pathogenic mechanisms are unknown. Here, we describe a genetic/epigenetic mechanism by which a newly identified TG promoter...
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