Article
Precore codon 28 stop mutation in hepatitis B virus from patients with hepatocellular carcinoma.
The Korean journal of internal medicine - 1 Jun 1997
Park Y M, Kim B S, Tabor E
Abstract excerpt
OBJECTIVES: Hepatitis B virus (HBV) with a stop mutation at precore codon 28 (TGG-->TAG, tryptophan-->stop) was investigated to clarify if such a mutant virus might play a role in hepatocarcinogenesis. METHODS: A total of 73 patients with HBV-related hepatocellular carcinoma were included in this study. Polymerase chain reaction (PCR) was performed in DNA samples extracted from 73 sera to amplify a HBV-DNA...
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