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Cellular senescence and cancer

1 Jan 1999

Abstract excerpt

The proliferative lifespan of normal mammalian cells is limited by intrinsic controls, which desensitize the cell-cycle machinery to extrinsic stimulation after a given number of cell divisions. One underlying clock driving this process of 'replicative senescence' is the progressive erosion of chromosome telomeres, which occurs with each round of DNA replication. This appears to trigger growth inhibition via...

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PMID: 10341711
DOI: 10.1002/(sici)1096-9896(199901)187:1<100::aid-path236>3.0.co;2-t

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