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Article

Function of JunB in Transient Amplifying Cell Senescence and Progression of Human Prostate Cancer

15 Jul 2008

Abstract excerpt

PURPOSE: Replicative senescence in cells acts as a barrier against excessive proliferation and carcinogenesis. Transient amplifying cells (TAC) are a subset of basal cell populations within the prostate from which cancers are thought to originate; therefore, we focused on prostate TAC to investigate the molecular mechanisms by which the TAC may be able to evade senescence. EXPERIMENTAL DESIGN: TAC clones were...

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PMID: 18628455
DOI: 10.1158/1078-0432.ccr-07-4120

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