Article
A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin American Aedes aegypti.
Insect molecular biology - 1 Dec 2007
Saavedra-Rodriguez K, Urdaneta-Marquez L, Rajatileka S, Moulton M, Flores A E, Fernandez-Salas I, Bisset J, Rodriguez M, McCall P J, Donnelly M J, Ranson H, Hemingway J, Black W C
Abstract excerpt
Pyrethroids are commonly used as mosquito adulticides and evolution of resistance to these compounds is a major threat to public health. 'Knockdown resistance' to pyrethroids (kdr) is frequently caused by nonsynonymous mutations in the voltage-gated sodium channel transmembrane protein (para) that reduce pyrethroid binding. Early detection of kdr is critical to the development of resistance management strategies...
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