Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling.

Pest management science - 1 Nov 2008

Davies Tg Emyr, O'Reilly Andrias O, Field Linda M, Wallace Ba, Williamson Martin S

Abstract excerpt

Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes. The correct functioning of these channels is essential for the normal transmission of nerve impulses, and this process is disrupted by binding of the insecticides, leading to paralysis and eventual death. Some...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DDT
Share to Insecta
Share to Insecticide Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insecticides

Share to Models, Molecular

Share to Mutation

Share to Pyrethrins

Share to Sodium Channels

Source

Identifiers

PMID: 18561309
DOI: 10.1002/ps.1617

Genes

DDT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling.PMID 18561309Read ↗

Knockdown resistance to DDT and pyrethroids in the house fly (Diptera: Muscidae): from genetic trait to molecular mechanism.Semantic proximity Read ↗

The molecular biology of knockdown resistance to pyrethroid insecticides.Semantic proximity Read ↗

Recent advances in the study of knockdown resistance mutations in Aedes mosquitoes with a focus on several remarkable mutations.Semantic proximity Read ↗

Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegyptiSemantic proximity Read ↗

Knockdown resistance in mosquito vectors: Molecular mechanisms, global spread, and future directions for sustainable vector control.Semantic proximity Read ↗

Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels.Semantic proximity Read ↗

Characterization of two kdr mutations at predicted pyrethroid receptor site 2 in the sodium channels of Aedes aegypti and Nilaparvata lugens.Semantic proximity Read ↗

The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.Semantic proximity Read ↗

Differential resistance of insect sodium channels with kdr mutations to deltamethrin, permethrin and DDT.Semantic proximity Read ↗

Functional Characterization of Knockdown Resistance Mutation L1014S in the German Cockroach, Blattella germanica (Linnaeus).Semantic proximity Read ↗

Overcoming super-knock down resistance (super-kdr) mediated resistance: multi-halogenated benzyl pyrethroids are more toxic to super-kdr than kdr house flies.Semantic proximity Read ↗

Toward Overcoming Pyrethroid Resistance in Mosquito Control: The Role of Sodium Channel Blocker Insecticides.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.