Article
Diversity of Immunoglobulin Light Chain Genes in Non-Teleost Ray-Finned Fish Uncovers IgL Subdivision into Five Ancient Isotypes.
Frontiers in immunology - 1 Jan 2018
Guselnikov Sergey V, Baranov Konstantin O, Najakshin Alexander M, Mechetina Ludmila V, Chikaev Nikolai A, Makunin Alexey I, Kulemzin Sergey V, Andreyushkova Daria A, Stöck Matthias, Wuertz Sven, Gessner Jörn, Warren Wesley C, Schartl Manfred, Trifonov Vladimir A, Taranin Alexander V
Abstract excerpt
The aim of this study was to fill important gaps in the evolutionary history of immunoglobulins by examining the structure and diversity of IgL genes in non-teleost ray-finned fish. First, based on the bioinformatic analysis of recent transcriptomic and genomic resources, we experimentally characterized the IgL genes in the chondrostean fish, Acipenser ruthenus (sterlet). We show that this species has three loci...
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