Article
Combined genetic polymorphism and risk for development of lung cancer.
Mutation research - 28 Nov 1997
el-Zein R, Zwischenberger J B, Wood T G, Abdel-Rahman S Z, Brekelbaum C, Au W W
Abstract excerpt
Susceptibility to lung cancer has been shown to be modulated by host specific factors. Inheritance of different polymorphic cytochrome P450s (CYPs) and the glutathione S-transferases (GSTs) which affect metabolism of environmental toxicants may play a key role in individual susceptibility. Althou...
Topics
- Adult
- Biotransformation
- Carcinogens
- Case-Control Studies
- Cocarcinogenesis
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP2E1
- DNA Mutational Analysis
- Disease Susceptibility
- Female
- Genetic Heterogeneity
- Genotype
- Glutathione Transferase
- Humans
- Isoenzymes
- Lung Neoplasms
- Male
- Middle Aged