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Article

Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis.

Carcinogenesis - 1 Sept 2007

Vineis Paolo, Anttila Sisko, Benhamou Simone, Spinola Monica, Hirvonen Ari, Kiyohara Chikako, Garte Seymour J, Puntoni Riccardo, Rannug Agneta, Strange Richard C, Taioli Emanuela

Abstract excerpt

To test the hypothesis of interaction among genetic variants in increasing the individual risk of cancer, we have studied the cumulative effect on lung cancer risk of variants in three metabolic genes, CYP1A1, GSTM1 and GSTT1, which are involved in the metabolism of the tobacco smoke constituents...

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Source

Identifiers

PMID: 17307802
DOI: 10.1093/carcin/bgm039

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17307802-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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