Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity.

Abstract excerpt

Yeast with defects in vacuolar pH show increased sensitivity to high concentrations of transition metals. This sensitivity has been presumed to result from defective metal storage. We demonstrate that mutations that result in a defective high affinity iron transport system, such as a deletion in the surface ferroxidase FET3, also result in increased metal sensitivity independent of vacuolar function. Multiple...

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