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Article

Manganese toxicity and Saccharomyces cerevisiae Mam3p, a member of the ACDP (ancient conserved domain protein) family.

The Biochemical journal - 15 Mar 2005

Yang Mei, Jensen Laran T, Gardner Allison J, Culotta Valeria C

Abstract excerpt

Manganese is an essential, but potentially toxic, trace metal in biological systems. Overexposure to manganese is known to cause neurological deficits in humans, but the pathways that lead to manganese toxicity are largely unknown. We have employed the bakers' yeast Saccharomyces cerevisiae as a model system to identify genes that contribute to manganese-related damage. In a genetic screen for yeast...

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Identifiers

PMID: 15498024
DOI: 10.1042/BJ20041582
PMCID: PMC1134866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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