Article
A permease-oxidase complex involved in high-affinity iron uptake in yeast.
Science (New York, N.Y.) - 15 Mar 1996
Stearman R, Yuan D S, Yamaguchi-Iwai Y, Klausner R D, Dancis A
Abstract excerpt
Iron must cross biological membranes to reach essential intracellular enzymes. Two proteins in the plasma membrane of yeast--a multicopper oxidase, encoded by the FET3 gene, and a permease, encoded by the FTR1 gene--were shown to mediate high-affinity iron uptake. FET3 expression was required for FTR1 protein to be transported to the plasma membrane. FTR1 expression was required for apo-FET3 protein to be loaded...
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