Article
A technique for eliminating allele specific amplification failure during DNA amplification of heterozygous cells for preimplantation diagnosis.
Molecular human reproduction - 1 Nov 1997
El-Hashemite N, Delhanty J D
Abstract excerpt
Advances in techniques of molecular biology have made possible the amplification of specific genes from single cells. This has a major clinical application in preimplantation diagnosis of monogenic disorders. However, the incidence of allele specific amplification failure (allele drop out) in het...
Topics
- Alleles
- DNA
- Female
- Fertilization in Vitro
- Heterozygote
- Humans
- Male
- Preimplantation Diagnosis