Article
Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees.
Genetic epidemiology - 1 Jan 1997
Graham J, Chapman N H, Goddard K A, Goode E L, Wijsman E M, Jarvik G P
Abstract excerpt
Goals of this analysis were to map loci contributing to variation in the quantitative trait, Q1, using the lod-score method on data set 1, and to explore the difference in power to map genes when considering the discrete vs. quantitative phenotype. Segregation analyses, after covariate adjustment, correctly suggested two contributing loci. The major gene on chromosome 5 was successfully mapped, but the major gene...
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