Article
How can maximum likelihood methods reveal candidate gene effects on a quantitative trait?
Genetic epidemiology - 1 Jan 1995
Martinez M, Abel L, Demenais F
Abstract excerpt
Different maximum likelihood approaches were used to explore the role of candidate genes in the variability of quantitative trait Q1 while accounting for the effects of age, Q2, and Q3. Segregation analysis, under the class D regressive model, provides evidence for a Mendelian gene effect on the adjusted trait Q1. Results of gene mapping through lod-score analyses remain puzzling. Pairwise lod scores indicate a...
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