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Article

NMDA receptor-dependent refinement of somatotopic maps.

Neuron - 1 Dec 1997

Iwasato T, Erzurumlu R S, Huerta P T, Chen D F, Sasaoka T, Ulupinar E, Tonegawa S

Abstract excerpt

We have examined the role of NMDA receptor-mediated neural activity in the formation of periphery-related somatosensory patterns, using genetically engineered mice. We demonstrate that ectopic expression of a transgene of an NMDAR1 splice variant rescues neonatally fatal NMDAR1 knockout (KO) mice, although the average life span varies depending on the level of the transgene expression. In NMDAR1 KO mice with...

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PMID: 9427244
DOI: 10.1016/s0896-6273(00)80412-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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