Article
NMDA receptor-dependent refinement of somatotopic maps.
Neuron - 1 Dec 1997
Iwasato T, Erzurumlu R S, Huerta P T, Chen D F, Sasaoka T, Ulupinar E, Tonegawa S
Abstract excerpt
We have examined the role of NMDA receptor-mediated neural activity in the formation of periphery-related somatosensory patterns, using genetically engineered mice. We demonstrate that ectopic expression of a transgene of an NMDAR1 splice variant rescues neonatally fatal NMDAR1 knockout (KO) mice...
Topics
- Alternative Splicing
- Animals
- Brain
- Electron Transport Complex IV
- Electrophysiology
- Genetic Engineering
- Genetic Variation
- In Situ Hybridization
- In Vitro Techniques
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Knockout
- Mice, Transgenic
- NADPH Dehydrogenase
- Neurons
- Patch-Clamp Techniques
- Receptors, N-Methyl-D-Aspartate