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Article

Neurofibromin Is Required for Barrel Formation in the Mouse Somatosensory Cortex

13 Feb 2008

Abstract excerpt

The rodent barrel cortex is a useful system to study the role of genes and neuronal activity in the patterning of the nervous system. Several genes encoding either intracellular signaling molecules or neurotransmitter receptors are required for barrel formation. Neurofibromin is a tumor suppressor protein that has Ras GTPase activity, thus attenuating the MAPK (mitogen-activated protein kinase) and and PI-3...

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PMID: 18272679
DOI: 10.1523/jneurosci.5236-07.2008

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