Article
Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour.
The European journal of neuroscience - 1 Feb 2006
Shi Tie-Jun Sten, Hua Xiao-Ying, Lu Xiaoying, Malkmus Shelle, Kinney Jeff, Holmberg Kristina, Wirz Sebastian, Ceccatelli Sandra, Yaksh Tony, Bartfai Tamas, Hökfelt Tomas
Abstract excerpt
Galanin is a 29-amino-acid peptide expressed in dorsal root ganglion (DRG) neurones and spinal dorsal horn neurones. It affects pain threshold and has developmental and trophic effects. Galanin acts at three G-protein-coupled receptors, galanin receptors (GalR1-3), each expressed in the DRGs as suggested by in situ hybridization and/or reverse transcriptase-polymerase chain reaction. The GalR2 knockout (-/-) mice...
Topics
- Age Factors
- Animals
- Axotomy
- Cell Count
- Cell Death
- Functional Laterality
- Galanin
- Ganglia, Spinal
- Gene Expression Regulation, Developmental
- Immunohistochemistry