Article
Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice.
Neuron - 1 Feb 1996
Kutsuwada T, Sakimura K, Manabe T, Takayama C, Katakura N, Kushiya E, Natsume R, Watanabe M, Inoue Y, Yagi T, Aizawa S, Arakawa M, Takahashi T, Nakamura Y, Mori H, Mishina M
Abstract excerpt
Multiple epsilon subunits are major determinants of the NMDA receptor channel diversity. Based on their functional properties in vitro and distributions, we have proposed that the epsilon 1 and epsilon 2 subunits play a role in synaptic plasticity. To investigate the physiological significance of the NMDA receptor channel diversity, we generated mutant mice defective in the epsilon 2 subunit. These mice showed no...
Topics
- Animals
- Animals, Newborn
- Animals, Suckling
- Hippocampus
- Long-Term Potentiation
- Mice
- Mice, Inbred C57BL
- Mutation
- Nerve Endings
- Neuronal Plasticity
- Neurons
- Receptors, N-Methyl-D-Aspartate
- Sensation