Article
Expanded trinucleotide CAG repeats in families with bipolar affective disorder.
Biological psychiatry - 15 Dec 1997
Mendlewicz J, Lindbald K, Souery D, Mahieu B, Nylander P O, De Bruyn A, Zander C, Engström C, Adolfsson R, Van Broeckhoven C, Schalling M, Lipp O
Abstract excerpt
Clinical anticipation has been reported in bipolar affective disorder (BPAD). The hypothesis that expanded trinucleotide repeats are related to anticipation and transmission pattern in families with bipolar affective disorder is tested in this study. Eighty-seven two-generation pairs of patients recruited from 29 bipolar families were analyzed. The repeat expansion detection method was used to detect CAG repeat...
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