Article
Anticipation is not associated with CAG repeat expansion in parent-offspring pairs of patients affected with schizophrenia.
American journal of medical genetics - 5 Feb 1999
Martorell L, Pujana M A, Valero J, Joven J, Volpini V, Labad A, Estivill X, Vilella E
Abstract excerpt
With the rationale that a disease that presents with anticipation could be associated with expansion of trinucleotide repeats, we selected parent-offspring pairs of schizophrenia patients with earlier age at onset in the filial generation to measure the expansion of CAG repeats using the repeat expansion detection (RED) method. Intergenerational comparisons were made for age at onset, length of CAG repeats, and...
Topics
- Adult
- Age of Onset
- Anticipation, Genetic
- Family Health
- Female
- Humans
- Male
- Models, Statistical
- Pedigree
- Phenotype
- Schizophrenia
- Sequence Analysis, DNA
- Trinucleotide Repeat Expansion