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Article

Anticipation and repeat expansion in bipolar disorder.

American journal of medical genetics. Part C, Seminars in medical genetics - 15 Nov 2003

O'Donovan Michael, Jones Ian, Craddock Nick

Abstract excerpt

Anticipation is the phenomenon whereby a disease becomes more severe and/or presents with earlier onset as it is transmitted down through generations of a family. The only known mechanism for true anticipation is a class of mutations containing repetitive sequences exemplified by the pathogenic trinucleotide repeat. Studies of bipolar disorder (BPD) are consistent with the presence of anticipation and, by...

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Identifiers

PMID: 14601032
DOI: 10.1002/ajmg.c.20009

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Source receipt: pubmed, retrieved 7 Sept 2026.

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