Article
G protein beta3 subunit variant: tendency of increasing susceptibility to hypertension in Japanese.
Blood pressure - 1 Jan 2001
Tozawa Y
Abstract excerpt
The mechanism of human G beta mutation, G beta3-s, to produce a "gain-of-function" G-protein signaling abnormality remains to be elucidated. Both the enhanced Gi-mediated signalings and the expression of G beta3-s have been demonstrated to be associated with hypertension, together with the finding that the T825 variant might be associated with the occurrence of a splice variant GNB3-s in a white population. The...
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