Article
Analysis of the retinoblastoma tumour suppressor gene in pancreatic endocrine tumours.
Clinical endocrinology - 1 Nov 1997
Chung D C, Smith A P, Louis D N, Graeme-Cook F, Warshaw A L, Arnold A
Abstract excerpt
OBJECTIVES: The molecular pathogenesis of human pancreatic endocrine tumours (PETs) is largely unknown. One attractive candidate gene for involvement in pancreatic endocrine neoplasia is the retinoblastoma (Rb) tumour suppressor gene. A deletion of the Rb gene was recently described in a human insulinoma. In addition, mice harbouring a null mutation in the Rb gene bred with p53 mutant mice develop pancreatic...
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