Article
Abnormalities of the RB1 and DCC tumor suppressor genes: uncommon in human pancreatic adenocarcinoma.
Molecular carcinogenesis - 1 Jun 1995
Barton C M, McKie A B, Hogg A, Bia B, Elia G, Phillips S M, Ding S F, Lemoine N R
Abstract excerpt
Evidence of RB1 allele loss was found in only 6% of pancreatic cancers, and we found no significant sequence abnormalities nor loss of RB protein expression in a panel of tumors and cell lines. Using reverse transcription-polymerase chain reaction and Southern blot analysis, we found no evidence for loss of DCC expression in pancreatic cancer cell lines, and allele loss only rarely in tumor biopsies. These...
Topics
- Adenocarcinoma
- Alleles
- Base Sequence
- Gene Deletion
- Gene Expression
- Genes, DCC
- Genes, Retinoblastoma
- Humans
- Immunohistochemistry
- Molecular Sequence Data
- Mutation