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Article

Functional Identification and Analysis of cis -Acting Sequences Which Mediate Genome Cleavage and Packaging in Human Herpesvirus 6

1 Jan 1998

Abstract excerpt

Sequences present at the genomic termini of herpesviruses become linked during lytic-phase replication and provide the substrate for cleavage and packaging of unit length viral genomes. We have previously shown that homologs of the consensus herpesvirus cleavage-packaging signals, pac1 and pac2, are located at the left and right genomic termini of human herpesvirus 6 (HHV-6), respectively. Immediately adjacent to...

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PMID: 9420230
DOI: 10.1128/jvi.72.1.320-329.1998

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