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Article

Sequences within the herpesvirus-conserved pac1 and pac2 motifs are required for cleavage and packaging of the murine cytomegalovirus genome.

Journal of virology - 1 Jan 1998

McVoy M A, Nixon D E, Adler S P, Mocarski E S

Abstract excerpt

The DNA sequence motifs pac1 [an A-rich region flanked by poly(C) runs] and pac2 (CGCGGCG near an A-rich region) are conserved near herpesvirus genomic termini and are believed to mediate cleavage of genomes from replicative concatemers. To determine their importance in the cleavage process, we constructed a number of recombinant murine cytomegaloviruses with a second cleavage site inserted at an ectopic location...

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Identifiers

PMID: 9420199
DOI: 10.1128/JVI.72.1.48-56.1998
PMCID: PMC109348

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