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Human cytomegalovirus DNA replicates after early circularization by concatemer formation, and inversion occurs within the concatemer

1 Feb 1994

Abstract excerpt

To determine the replicative mechanism for human cytomegalovirus (HCMV) DNA, field inversion gel electrophoresis was used to separate HCMV replicative DNAs during lytic infection. Unit-length circular HCMV genomes lacking terminal restriction fragments were detected starting 4 h after infection even when cells were treated with aphidicolin, phosphonoacetic acid, or cycloheximide. Viral DNA synthesis began 24 h...

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PMID: 8289333
DOI: 10.1128/jvi.68.2.1040-1051.1994

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