Article
Identification of concurrent germ-line mutations in hMSH2 and/or hMLH1 in Japanese hereditary nonpolyposis colorectal cancer kindreds.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 1997
Nakahara M, Yokozaki H, Yasui W, Dohi K, Tahara E
Abstract excerpt
We analyzed microsatellite instability, alterations of the polyadenine tract in TGF-beta RII (transforming growth factor beta type II receptor gene), and mutations of hMSH2 and hMLH1 in 32 patients with familial colorectal cancer (29 kindreds) fulfilling the clinical criteria for hereditary nonpo...
Topics
- Adaptor Proteins, Signal Transducing
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Carrier Proteins
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA-Binding Proteins
- Exons
- Female
- Genetic Markers
- Germ-Line Mutation
- Humans
- Japan
- Male
- Microsatellite Repeats
- Middle Aged
- MutL Protein Homolog 1