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Article

Evidence for distinct functions of MRE11 in Arabidopsis meiosis.

PloS one - 1 Jan 2013

Samanić Ivica, Simunić Juraj, Riha Karel, Puizina Jasna

Abstract excerpt

The evolutionary conserved Mre11/Rad50/Nbs1 complex functions as one of the guardians of genome integrity in eukaryotes; it is required for the double-strand break repair, meiosis, DNA checkpoint, and telomere maintenance. To better understand the role of the MRE11 gene in Arabidopsis, we performed comparative analysis of several mre11 alleles with respect to genome stability and meiosis. The mre11-4 and mre11-2...

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Source

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Identifiers

PMID: 24205310
DOI: 10.1371/journal.pone.0078760
PMCID: PMC3804616

Genes

MRE11
ATM
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Evidence for distinct functions of MRE11 in Arabidopsis meiosis.PMID 24205310Read ↗

Severe developmental defects, hypersensitivity to DNA-damaging agents, and lengthened telomeres in Arabidopsis MRE11 mutants.Semantic proximity Read ↗

Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination.Semantic proximity Read ↗

Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance.Semantic proximity Read ↗

The multiple roles of the Mre11 complex for meiotic recombination.Semantic proximity Read ↗

Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.Semantic proximity Read ↗

The plant Rad50-Mre11 protein complex.Semantic proximity Read ↗

A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis.Semantic proximity Read ↗

Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination.Semantic proximity Read ↗

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mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis.Semantic proximity Read ↗

Xrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination.Semantic proximity Read ↗

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