Article
mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis.
Genes & development - 1 Sept 1997
Nairz K, Klein F
Abstract excerpt
During meiotic prophase the repair of self-inflicted DNA double-strand break (DSB) damage leads to meiotic recombination in yeast. We employed a genetic screen to specifically characterize cellular functions that become essential after this DSB formation. As a result a new allele of MRE11, termed...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- DNA Damage
- DNA Primers
- DNA Repair
- DNA, Fungal
- Dimerization
- Endodeoxyribonucleases
- Exodeoxyribonucleases
- Fungal Proteins
- Genes, Fungal
- Genetic Complementation Test
- In Situ Hybridization, Fluorescence
- Meiosis
- Microscopy, Electron
- Models, Biological
- Molecular Sequence Data