Article
Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity.
Molecular pharmacology - 1 Dec 1997
McLellan R A, Oscarson M, Alexandrie A K, Seidegård J, Evans D A, Rannug A, Ingelman-Sundberg M
Abstract excerpt
The mu class glutathione S-transferase gene GSTM1 is polymorphic in humans, with approximately half of the Caucasian population being homozygous deleted for this gene. GSTM1 enzyme deficiency has been suggested to predispose people to lung and bladder cancer. Some people in a Saudi Arabian popula...
Topics
- Binding Sites
- Blotting, Southern
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Genotype
- Glutathione Transferase
- Humans
- Isoenzymes
- Multigene Family
- Polymerase Chain Reaction