Article
Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models.
American journal of medical genetics - 19 Dec 1997
Maestri N E, Beaty T H, Hetmanski J, Smith E A, McIntosh I, Wyszynski D F, Liang K Y, Duffy D L, VanderKolk C
Abstract excerpt
Extensive epidemiological and genetic studies of the cause of oral clefts have demonstrated strong familial aggregation but have failed to yield definitive evidence of any single genetic mechanism. We used the transmission/disequilibrium test (TDT) to investigate the relationship between oral cle...
Topics
- B-Cell Lymphoma 3 Protein
- Cleft Lip
- Cleft Palate
- Environmental Exposure
- Genetic Linkage
- Genetic Markers
- Genotype
- Humans
- Linkage Disequilibrium
- Logistic Models
- Models, Genetic
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Receptors, Retinoic Acid