Article
Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models.
American journal of medical genetics - 19 Dec 1997
Maestri N E, Beaty T H, Hetmanski J, Smith E A, McIntosh I, Wyszynski D F, Liang K Y, Duffy D L, VanderKolk C
Abstract excerpt
Extensive epidemiological and genetic studies of the cause of oral clefts have demonstrated strong familial aggregation but have failed to yield definitive evidence of any single genetic mechanism. We used the transmission/disequilibrium test (TDT) to investigate the relationship between oral clefts and markers associated with five candidate genes by utilizing 160 parent-offspring trios. Conditional logistic...
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