Article
Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas.
Japanese journal of cancer research : Gann - 1 Oct 1997
Kudo Y, Yasui W, Ue T, Yamamoto S, Yokozaki H, Nikai H, Tahara E
Abstract excerpt
CDC25 phosphatases activate cyclin-dependent kinases by removing inhibitory phosphate groups on the molecules and positively regulate the cell cycle progression. The expression of CDC25A, B and C was examined in gastric carcinoma cell lines and gastric carcinoma tissues by northern blotting and immunohistochemistry. The gastric carcinoma cell lines expressed CDC25A, B and C mRNA at various levels. The expression...
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