Article
Combined effect of HLA-DRB1*1501 and interleukin-1 receptor antagonist gene allele 2 in susceptibility to relapsing/remitting multiple sclerosis.
Journal of neuroimmunology - 1 Dec 1997
de la Concha E G, Arroyo R, Crusius J B, Campillo J A, Martin C, Varela de Seijas E, Peña A S, Clavería L E, Fernandez-Arquero M
Abstract excerpt
Susceptibility to multiple sclerosis (MS) is associated with HLA-DRB1*1501. Many reports have suggested associations with other loci but these results remain unconfirmed. We studied the IL-1 receptor antagonist (IL-1ra) gene polymorphism and the HLA-DR and DQ allele frequencies by DNA-based methods in both the primary chronic progressive form (PP MS) and the relapsing/remitting form (R/R MS). The frequency of...
Topics
- Alleles
- Case-Control Studies
- Disease Progression
- Disease Susceptibility
- Female
- Gene Frequency
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Male
- Multiple Sclerosis
- Random Allocation