Article
High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis.
Clinical immunology (Orlando, Fla.) - 1 Oct 2010
Shahbazi Majid, Roshandel Danial, Ebadi Hamid, Fathi Davood, Zamani Mahdi, Boghaee Mojdeh, Mohammadhoseeeni Mana, Rshaidbaghan Azam, Bakhshandeh Azam, Shahbazi Saleh
Abstract excerpt
We have evaluated the role of the HLA-DRB1*1501 allele and the IL-2 -330 T/G polymorphism and their interaction in susceptibility to multiple sclerosis on 360 patients and 426 matched healthy individuals. We used the SSP-PCR method to determine the alleles. Fisher's exact test was used to analyses. We observed a significant increase in the T allele at IL-2 -330 position in patients (OR=1.34, P<0.05), and the T/T...
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